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Find a Trial

Active Cardiovascular Clinical Trials

Phase 1 to Phase 3 studies enrolling at our Miami research site. Browse the list below and request a free pre-screen.

Clinical trial participation requires eligibility screening and informed consent. Website content is informational and is not a substitute for medical advice from a licensed clinician.

Phase 3HypertensionCurrently Recruiting

ZENITH — Zilebesiran (RNAi)

Treatment-Resistant Hypertension

Study purpose
To evaluate whether zilebesiran, an investigational RNA-interference therapy, lowers blood pressure and cardiovascular risk in adults whose hypertension is not controlled by multiple medications.
Who may qualify
Adults 18+ with high blood pressure that has not been controlled despite taking three or more medications.
Commitment
Multiple in-clinic visits over the trial period; visit cadence and total length confirmed at screening.
Location
Amavita Research · North Miami Beach, FL

Sponsor: Alnylam Pharmaceuticals · ClinicalTrials.gov ID: Ask our research team

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Phase 3ACSCurrently Recruiting

Librexia ACS

Acute Coronary Syndrome

Study purpose
To test whether a novel antithrombotic strategy reduces cardiovascular events after a recent acute coronary syndrome.
Who may qualify
Adults who recently experienced an acute coronary syndrome (heart attack or unstable angina) and are clinically stable.
Commitment
Scheduled follow-up visits over the duration of the study; details confirmed at screening.
Location
Amavita Research · North Miami Beach, FL

Sponsor: Pfizer · ClinicalTrials.gov ID: NCT05754957

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Phase 2Heart FailureRecruiting

JK07 — Heart Failure

Heart Failure (across EF ranges)

Study purpose
To evaluate the safety and effect of a novel investigational heart failure therapy across the full spectrum of ejection fraction.
Who may qualify
Adults 18–85 with chronic heart failure (NYHA Class II–III) on stable, guideline-directed medications.
Commitment
Periodic clinic visits with cardiac assessments; full schedule shared at screening.
Location
Amavita Research · North Miami Beach, FL

Sponsor: JK07 Bio · ClinicalTrials.gov ID: NCT06369298

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Phase 3Heart FailureRecruiting

IV Ferric Derisomaltose

Iron-Deficient Heart Failure

Study purpose
To evaluate whether intravenous iron replacement improves outcomes and quality of life in adults with heart failure and iron deficiency.
Who may qualify
Adults with heart failure (reduced or preserved ejection fraction) who also have lab-confirmed iron deficiency.
Commitment
Infusion visits and follow-up assessments over the study period.
Location
Amavita Research · North Miami Beach, FL

Sponsor: Pharmacosmos · ClinicalTrials.gov ID: Ask our research team

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Phase 1Heart FailureEnrolling Soon

Phase 1 HFpEF — VS-041

HFpEF

Study purpose
First-in-human safety and pharmacology study of an investigational therapy targeting cardiac structural remodeling in HFpEF.
Who may qualify
Adults 40–80 with heart failure and preserved ejection fraction (LVEF ≥ 50%) and elevated cardiac biomarkers.
Commitment
Closely monitored visits typical of a Phase 1 study; cadence reviewed during screening.
Location
Amavita Research · North Miami Beach, FL

Sponsor: VASA Therapeutics · ClinicalTrials.gov ID: Ask our research team

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Phase 2Heart FailureRecruiting

HFpEF — PF-07328948

HFpEF (Metabolic Therapy)

Study purpose
To evaluate a metabolic-pathway therapy for symptomatic improvement in adults with HFpEF.
Who may qualify
Adults with confirmed HFpEF and BMI ≥ 27 on stable cardiovascular medications.
Commitment
Clinic visits with symptom and biomarker assessments over the trial period.
Location
Amavita Research · North Miami Beach, FL

Sponsor: Pfizer · ClinicalTrials.gov ID: Ask our research team

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Phase 3VascularRecruiting

Golazo® GREAT — Peripheral Atherectomy

Peripheral Artery Disease

Study purpose
To evaluate the safety and effectiveness of an advanced peripheral atherectomy system for calcified lower-extremity peripheral artery disease.
Who may qualify
Adults 18+ with symptomatic peripheral artery disease (Rutherford Class 2–4) and a suitable target lesion on imaging.
Commitment
Procedure with structured post-procedure follow-up; details reviewed at screening.
Location
Advanced Cardiovascular of Miami (affiliated ASC) · Miami, FL

Sponsor: Cardiovascular Systems Inc. · ClinicalTrials.gov ID: Ask our research team

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