Site comparison
Amavita Research vs. Centers For Imaging & Research Of America (CIRA): which clinical trial site fits your study?
Sponsors running cardiovascular trials in South Florida sometimes encounter two very different kinds of research vendor: a cardiac imaging center and a full-service clinical trial site. This page explains the difference factually so you can engage the right research vendor for the work in front of you.
Amavita Research is a full-service clinical trial site and PET imaging trial partner in North Miami Beach, anchored by a dedicated cardiovascular research site. It enrolls patients, runs therapeutic and device protocols end to end - screening, treatment, procedures, follow-up - across heart failure, hypertension, acute coronary syndrome, structural heart, and peripheral artery disease. The senior PI is U.S. TAVR pioneer Dr. William W. O'Neill, National PI on Edwards PARTNER, Protect II, and Protect IV. Site processes are IAOCR GCSA-certified, valid through February 28, 2027.
Centers For Imaging & Research Of America (CIRA) is a Miami-based molecular imaging center focused on outpatient diagnostic imaging, with emphasis on oncology, cardiology, neurology, and vascular disease. CIRA describes itself as the first introducer of cardiac PET imaging to South Florida and the first private center in Florida to offer N-13 Ammonia cardiac PET with coronary flow reserve and calcium scoring. Its research emphasis is molecular imaging research.
The distinction matters because the two organizations do different jobs in a trial. An imaging center provides imaging: cardiac PET scans, reads, and imaging-based research support. A clinical trial site provides the trial itself: patient enrollment, investigational treatment administration, safety follow-up, and regulatory-grade data capture across the full protocol.
For a sponsor that needs cardiac imaging reads or imaging biomarker support, a dedicated PET imaging center is the right call. For a sponsor that needs an enrolling site to run a cardiovascular protocol - patients recruited, treated, and followed under one PI team - the full-service trial site is the right call. Many programs need both, with the imaging center supporting reads and the trial site executing the protocol.
Amavita also brings cardiac PET and radiopharmaceutical trial capability through its qualified imaging network for the growing pipeline of CV imaging-tracer studies, alongside an anonymized 41-day contract-to-first-patient-in metric, a single BD owner (Nereisy Alonso, COO), and a diverse Miami enrollment population that supports FDA Diversity Action Plan targets.
Side-by-side: operating model
Educational summary. We describe the typical cardiac imaging center model and do not make claims about any specific institution's current operations.
| Dimension | Amavita Research | CIRA (typical) |
|---|---|---|
| Organization type | Full-service cardiovascular clinical trial site | Outpatient molecular imaging center |
| Primary service | End-to-end trial execution: enrollment, treatment, follow-up | Diagnostic imaging with molecular imaging research emphasis |
| Cardiac PET | Cardiac PET and radiopharmaceutical trial capability | First introducer of cardiac PET imaging to South Florida; N-13 Ammonia PET |
| Therapeutic protocols | 7 active cardiovascular studies across HF, hypertension, ACS, structural heart, PAD | Imaging-focused; not a therapeutic trial site |
| Senior PI profile | TAVR pioneer Dr. William W. O'Neill; National PI on Edwards PARTNER, Protect II, Protect IV | Nuclear medicine and imaging physician team |
| Quality framework | IAOCR GCSA-certified, valid through February 28, 2027 | Diagnostic imaging accreditation |
| Best fit | Sponsors needing an enrolling cardiovascular trial site | Sponsors needing cardiac imaging reads or imaging support |
Frequently asked questions
Is CIRA a clinical trial site?
CIRA is a molecular imaging center with a research emphasis on imaging. It provides cardiac PET imaging and imaging research support; it is not a full-service therapeutic trial site that enrolls and manages patients across a drug or device protocol.
When should a sponsor engage an imaging center versus a trial site?
Engage the imaging center for imaging reads, imaging biomarkers, and PET-based endpoints. Engage the trial site for patient enrollment, investigational treatment, safety follow-up, and full protocol execution.
Can a program use both?
Yes, and imaging-intensive programs often do: the trial site executes the protocol and enrolls patients, while the imaging center provides standardized reads and imaging biomarker support.
Does Amavita support imaging-tracer cardiovascular trials?
Yes. Amavita has cardiac PET and radiopharmaceutical trial capability for the growing pipeline of cardiovascular imaging-tracer studies, in addition to its therapeutic and device trial portfolio.
Where is CIRA located?
CIRA is a Miami-based molecular imaging center. Its website lists multiple South Florida locations, including Miami, Miami Beach, and Sarasota. Amavita Research's clinical trial site is in North Miami Beach at 100 NW 170 Street, Suite 305.
Can a sponsor run a drug or device trial at CIRA?
CIRA's research emphasis is molecular imaging research — imaging endpoints, reads, and imaging biomarker support. A drug or device protocol that requires patient enrollment, investigational treatment administration, and safety follow-up needs a full-service trial site. Amavita Research enrolls and runs cardiovascular protocols end to end.
Next step
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For a comprehensive sponsor decision framework, read our 2026 site selection guide.
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