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Leadership & About

World-Class Cardiovascular Leadership

Amavita Research is led by globally recognized investigators bringing decades of breakthrough cardiovascular experience to Miami.

About Amavita Research

Amavita Research is the clinical research division of amavita Heart and Vascular Health®, a private cardiology practice in North Miami Beach, FL. Operating as Amavita Research Services LLC, the trial site is structured as an independent investigator-led research operation embedded inside an active cardiology practice. The practicing cardiologists who treat patients in routine clinical care also serve as Principal Investigators on cardiovascular trials, producing continuous patient flow and consistent PI engagement that database-recruited or rotating-PI sites cannot match.

Part of the Amavita / bioaccess Miami group

bioaccess®, Amavita Research, Amavita Sciences™, and amavita Heart and Vascular Health® are sister companies in the same Miami group: the First-in-Human CRO and LATAM registration/IOR holder, a GCSA-certified Miami cardiovascular trial site, LATAM regulatory-translation infrastructure, and the South Florida cardiovascular practice.

Our mission

Amavita Research's mission is to accelerate the development of new treatments by serving as a high-quality, independent cardiovascular clinical trial site for sponsors who value PI continuity, named accountability, predictable patient flow, and capital efficiency. Our Miami site focuses on cardiovascular indications — hypertension, heart failure, acute coronary syndrome, peripheral artery disease, iron deficiency in heart failure, and related conditions — where our practicing cardiologist PIs have deep subspecialty experience.

Our affiliations

  • Parent organization: amavita Heart and Vascular Health® — a private cardiology practice with active cath-lab access, electrophysiology capability, and a continuously-recruiting patient base. The trial site shares space, staff, and procedural infrastructure with the practice.
  • Affiliated surgical center: Advanced Cardiovascular of Miami — ambulatory surgical center providing extended cath-lab and interventional capacity.
  • Sister organization: bioaccess® — first-in-human CRO with 50+ delivered FIH programs since 2010; together Amavita Research + bioaccess® support sponsors running integrated Americas trial designs under a single coordinated execution model.

Our certifications and quality framework

IAOCR GCSA Certification Mark — Amavita Research Services LLC, GCSA-certified (Feb 2025)
  • IAOCR GCSA-certified (Feb 2025) — Certification ID 2802-AMAX1-GC-MAY26, GCSA-certified (Feb 2025)
  • ICH-GCP E6(R3) compliant
  • SCRS (Society for Clinical Research Sites) member
  • HIPAA-compliant patient data handling

Our leadership

Where we are

Both locations are operating now. Amavita Research's legal address, clinical trial site and heart practice are at 100 NW 170 St, Suite 305, North Miami Beach, FL 33169. The cardiovascular surgery center is at 9408 SW 87th Ave, Suite 303, Miami, FL 33176. For full site details, see our location page at /locations/north-miami-beach.

Who we serve

Portrait of Dr. William W. O'Neill, Chief Medical Officer
FACCStructural Heart ResearchStructural Heart

Featured Leadership

Chief Medical Officer & Senior PI

Dr. William W. O'Neill, MD, FACC

Chief Medical Officer & Senior Principal Investigator

Medical Director, Center for Structural Heart Disease, Henry Ford Hospital · Chief Medical Advisor, CardioElite™ · Internationally renowned interventional cardiologist with a structural-heart (TAVR) research background.

TAVR

Structural-heart research background

45+

Years in cardiovascular medicine

3

Research leadership roles: PROTECT II (national PI), PROTECT IV (steering committee), PARTNER (site PI)

Structural Heart Research

  • Medical Director, Center for Structural Heart Disease, Henry Ford Hospital (2012–present)
  • Structural-heart (TAVR) research background
  • Principal Investigator at Henry Ford for the PARTNER trial
  • National Principal Investigator (chair) of PROTECT II; Steering Committee member for PROTECT IV

Academic Leadership

  • Executive Dean for Clinical Affairs, University of Miami Miller School of Medicine
  • Chief Medical Officer, University of Miami Health System (2006–2012)
  • Professor of Medicine with tenure, University of Miami & University of Michigan
  • Director, Division of Cardiovascular Disease, William Beaumont Hospital (1987–2006)

Credentials & Training

  • MD, Wayne State University School of Medicine
  • Cardiology Fellowship, University of Michigan
  • Fellow, American College of Cardiology (FACC)
  • 45+ years of cardiovascular medicine experience

Research & Innovation

  • Yearly Editor, Annual Review of PCI published in JACC
  • Principal Investigator for multiple FDA device trials
  • Advancing structural heart therapies and mechanical circulatory support
  • Medical device innovation consultant for leading companies
Portrait of Dr. Pedro Martinez-Clark
FACCHarvard-TrainedTrans-Caval TAVRWorldwide PI

Co-Investigator & Cardiology Lead

Founder & CEO, amavita Heart and Vascular Health®

Dr. Pedro Martinez-Clark, MD, FACC

Founder and Lead Investigator

15+

Years of cardiovascular experience

more than 25

Clinical research trials led

2023

Apogee Award for Excellence in Healthcare

Dr. Pedro Martinez-Clark began his medical career in Colombia before moving to the United States for advanced training. He completed research at Harvard, his medical residency at Case Western Reserve University, and returned to Harvard for specialized training in cardiovascular and interventional cardiology.

He later joined the University of Miami as a professor and physician, working alongside renowned cardiologist Dr. William O'Neill on complex structural-heart cases. Dr. Martinez-Clark has led more than 25 clinical research trials, contributed to the development of the Trans-Caval approach to transcatheter aortic valve replacement, and served as Worldwide Principal Investigator on the Percutaneous Mitral Valve Annuloplasty trial. Marquee studies he has run or is currently running include CYCLE (heart failure), CHAMP-HF Registry, GREAT (Golazo® peripheral atherectomy), Pathfinder I (AURYON), Percutaneous Mitral Valve Annuloplasty, and SPARE-MR.

He is a Fellow of the American College of Cardiology (FACC) and recipient of the 2023 Apogee Award for Excellence in Healthcare. In 2017 he founded amavita Heart and Vascular Health®, where he serves as CEO. Today amavita is an independent Miami cardiovascular practice; 16,000+ patients seen in the last 3 years — and Amavita Research is its dedicated research arm. The practice works with Jackson Memorial and Mercy Hospitals while remaining independent to keep patients first.

Clinical Specialties

  • Cardiovascular & interventional cardiology
  • Cardiac catheterization
  • Coronary revascularization
  • Heart valve repair & replacement
  • Venous ablation
  • Peripheral artery disease treatments

Personal Investigator Credentials

Held by Dr. Martinez-Clark individually — not site-level accreditations.

ABIM Board Certified — Dr. Pedro Martinez-Clark, MD

Physician Credential

ABIM Board Certified

Certified by the American Board of Internal Medicine.

QM-IAOCR — Internationally Qualified Clinical Research Investigator (Reg 9851511, Dec 2024)

Investigator Credential

QM-IAOCR · Internationally Qualified Clinical Research Investigator

Independently accredited by IAOCR — Reg 9851511, Dec 2024.

Operations, Growth & Sponsor Liaison

The team behind every study

Senior contacts for sponsors, CROs, and monitors throughout study start-up and conduct.

Portrait of Julio G. Martinez-Clark
CEOStrategyLATAM ↔ US

Julio G. Martinez-Clark

Chief Executive Officer (CEO)

Drives growth strategy, sponsor relationships, and cross-border trial operations at Amavita Research. CEO of bioaccess® with 20+ years scaling clinical research operations across the Americas. Former Ambassador of IAOCR / GCSA Americas.

Portrait of Nereisy Alonso
COOOperationsStart-Up

Nereisy Alonso, Sr CRC

Chief Operations Officer (COO)

Senior Clinical Research Coordinator and operations lead. Owns site administration, sponsor monitor coordination, study start-up logistics, IRB submissions, and SOP SITE-107 KPI tracking on Monday.com across Amavita Research's active cardiovascular trial portfolio.

Portrait of Dr. Hans C. Rutzen-Lopez
ElectrophysiologyTriple Board-CertifiedEchocardiography

Dr. Hans C. Rutzen-Lopez, MD

Sub-Investigator, Cardiac Electrophysiology

Board-certified cardiac electrophysiologist with 9+ years of practice. Triple board-certified by the American Boards of Internal Medicine, Cardiovascular Disease, and Clinical Cardiac Electrophysiology, with the National Board of Echocardiography. Clinical Assistant Professor at Nova Southeastern University and electrophysiologist at Heart Rhythm Specialists of South Florida. Joined Amavita Research as Sub-Investigator on AnaCardio AC01-02 and other arrhythmia and device trials.

Portrait of Yasnaya Cruz-Santiago
BilingualPatient ScreeningAANP-Certified

Yasnaya Cruz-Santiago, APRN

Sub-Investigator

Florida-licensed Advanced Practice Registered Nurse (APRN #9443547), Family Nurse Practitioner (Universidad de Turabo, Puerto Rico, 2018), AANP-certified, and Florida-licensed RN since 2016. Bilingual (English / Spanish). Sub-Investigator on Amavita's active cardiovascular protocols, working closely with Dr. Pedro Martinez-Clark. Owns patient screening and informed consent, source data verification, sponsor monitor visit support, and visit-window adherence on the active portfolio.

Portrait of Angela Paez
PA-CNCCPA Board-CertifiedBilingual EN/ES/PTResearch-Trained

Angela Paez, PA-C

Sub-Investigator, Cardiovascular Physician Assistant

Board-certified Cardiovascular Physician Assistant with a Colombian medical degree (Universidad San Martin, Bogota, 2007) and 14+ years of research and clinical experience across the University of Miami Miller School of Medicine and Amavita Health. Trilingual in English, Spanish, and Portuguese. Co-author on peer-reviewed cardiovascular research (American Journal of Kidney Diseases, 2019).

Portrait of Vanessa Jimenez
PA-C · NCCPA CertifiedCardiovascular PA (since 2023)Bilingual EN/ESMMS — Saint Francis University

Vanessa Jimenez

Sub-Investigator, Cardiovascular Physician Assistant

NCCPA-Certified Physician Assistant (PA-C) and Florida-licensed Cardiovascular Physician Assistant at amavita Heart and Vascular Health® since 2023. MMS with Honors from Saint Francis University, Loretto, PA (2022); Bachelor in Physician Assistant Studies with Honors from Miami Dade College (2020); also a Foreign Medical Doctor (Universidad del Valle, Cali, Colombia, 2004). Bilingual in English and Spanish. Interprets 2D echocardiograms, stress tests, cardiac monitors, and vascular studies, and coordinates patient evaluations and care plans. Joins Amavita Research as Sub-Investigator on cardiovascular protocols.

    Portrait of Orlando Ortega-Izquierdo
    BilingualCath-Lab SupportProcedural Coordination

    Orlando Ortega-Izquierdo, APRN

    Sub-Investigator

    Florida-licensed Advanced Practice Registered Nurse (APRN #9442363), Family Nurse Practitioner (Universidad de Turabo, Puerto Rico, 2018, 3.92 GPA), and Florida-licensed RN since 2016. Bilingual (English / Spanish). Sub-Investigator on Amavita's interventional cardiovascular protocols, working closely with Dr. Pedro Martinez-Clark. Supports cath-lab study conduct, procedural-visit coordination, post-procedure follow-up, and informed consent.

    Portrait of Adidley Garcia
    GCSA CertifiedICH-GCP E6 (R3)

    Adidley Garcia

    Site Coordinator / Research Nurse

    Adidley Garcia coordinates clinical study operations at Amavita Research as Site Coordinator and Research Nurse, supporting trial conduct, participant care, and ICH-GCP E6 (R3) compliance at our Miami site.

      Portrait of Oscar Quintero
      MD (International Medical Graduate)Cardiology EducationClinical Quality & DocumentationBilingual EN/ES

      Oscar Quintero, MD

      Director of Clinical Education and Quality

      International medical graduate (Universidad del Rosario, Bogotá, Colombia, 2019, GPA 4.23) with focused experience in cardiovascular research coordination, medical education, and clinical quality. Director of Clinical Education and Quality at amavita Heart & Vascular and CardioElite™ since 2024; previously Research Coordinator at amavita Heart & Vascular (2022–2024), where he coordinated cardiovascular research operations including patient identification, data collection, protocol support, and cross-team coordination. Supports Amavita Research with clinical education for advanced-practice providers, documentation standards, workflow standardization, and quality oversight across cardiology trial workflows. Spanish native, English professional fluency.

        Parent Practice

        Amavita Research is the research arm of amavita Heart and Vascular Health®

        amavita Heart and Vascular Health® is an independent Miami cardiovascular practice; 16,000+ patients seen in the last 3 years . The practice is independent of any academic medical system.

        Patients are seen in-house through our affiliated cardiovascular practice. Our PIs are practicing cardiologists at amavita with active patient panels — they see trial-eligible patients in clinic every day. Sponsors get enrollment from a continuously-recruiting cardiology practice, not a CRO sourcing from referral networks.

        Our Mission

        To accelerate the development of safe, effective therapies by delivering trustworthy clinical data and exceptional patient experiences.

        Our Standards

        GCSA-certified · ICH-GCP E6 (R3) compliant. Audit-ready quality systems. Trilingual coordinators (English / Spanish / Haitian Creole); bilingual informed consent in English and Spanish.

        Our Community

        Rooted in Miami — one of the most ethnically and clinically diverse populations in the United States.

        Accreditations & Certifications

        Independently accredited site quality

        IAOCR GCSA Certified · The Global Quality Standard for Clinical Research Sites · ICH-GCP E6 (R3) compliant.

        IAOCR GCSA Certification Mark — Amavita Research Services LLC, GCSA-certified (Feb 2025)IAOCR — The International Accrediting Organization for Clinical Research

        Our Facility

        State-of-the-Art Research Suite

        Our North Miami Beach legal address, clinical trial site and heart practice are purpose-built for clinical research, with dedicated exam rooms, monitored study drug storage, on-site phlebotomy and processing, and secure document management. Our Kendall location is the operating cardiovascular surgery center.

        • Dedicated monitor workspace
        • -20°C / -80°C storage
        • On-site centrifuge & processing
        • Secure ePRO / EDC systems
        Modern clinical research exam room

        Our Facilities

        Advanced Cardiovascular of Miami

        A Cardiovascular & Radiology Surgery Center in Miami

        A licensed, Medicare-certified, AAAHC-accredited cardiovascular ASC in Kendall, Miami, affiliated with Amavita Research.

        Amavita Research patients and sponsor trials have direct access to affiliated Advanced Cardiovascular of Miami — a dedicated cardiovascular ambulatory surgery center in Miami with cath lab access for same-day procedures.

        Visit the surgery center site
        Advanced Cardiovascular of Miami catheterization lab

        Cardiology

        • Cardiac Catheterization
        • Cardiac Mapping & Ablation
        • Coronary Intervention
        • Implantable Cardiac Monitors
        • Pacemakers / ICDs / Bi-Ventricular Devices
        • Peripheral Artery & Vein Angiography & Intervention

        Interventional Radiology

        • Dialysis Access Management
        • Genicular / Hemorrhoidal / Prostate Artery Embolization
        • Kyphoplasty
        • Spinal Cord Stimulator Implantation
        • Uterine Fibroid Embolization

        Technology

        3D ImagingCardiac Mapping SystemCatheterization LabsMinimally Invasive Interventional SuitesOne-Stop Diagnosis-to-Intervention Workflow

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