Investigator profile
William W. O'Neill, MD, FACC
Chief Medical Officer & Senior Principal Investigator
Specialties
- Structural heart disease
- TAVR & transcatheter valve therapy
- High-risk PCI & cardiogenic shock
- Pivotal device trial leadership
Biography
Dr. William W. O'Neill is a senior principal investigator and interventional cardiologist with a structural-heart (TAVR) research background. He and has spent more than four decades advancing minimally invasive cardiovascular care.
Dr. O'Neill is the founding Medical Director of the Center for Structural Heart Disease at Henry Ford Hospital (2012–2023), now Medical Director Emeritus, and serves as Chief Medical Officer at Amavita Research. He has served as National Principal Investigator (chair) of the PROTECT II trial, Steering Committee member for PROTECT IV, and Principal Investigator at Henry Ford for the PARTNER trial, and is the founder of the National Cardiogenic Shock Initiative — a multi-center quality improvement program that established the modern standard of care for AMI cardiogenic shock.
He has authored or co-authored more than 400 peer-reviewed publications and has trained generations of interventional cardiologists. At Amavita Research he provides scientific oversight, protocol design input, and senior PI leadership across the active cardiovascular trial portfolio.
Education & Training
- MDWayne State University School of Medicine
- Internal Medicine ResidencyUniversity of Michigan
- Cardiovascular Disease FellowshipUniversity of Michigan
- FACCAmerican College of Cardiology
Selected Publications
Mack MJ, Leon MB, Thourani VH, … O'Neill WW, et al. N Engl J Med. 2019;380(18):1695–1705.
O'Neill WW, Kleiman NS, Moses J, et al. Circulation. 2012;126(14):1717–1727.
The Current Use of Impella 2.5 in Acute Myocardial Infarction Complicated by Cardiogenic Shock: Results from the USpella Registry
O'Neill WW, Schreiber T, Wohns DH, et al. J Interv Cardiol. 2014;27(1):1–11.
National Cardiogenic Shock Initiative: A Standardized Treatment Protocol for AMI Cardiogenic Shock
Basir MB, Kapur NK, Patel K, … O'Neill WW. Catheter Cardiovasc Interv. 2019;93(7):1173–1183.
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